| Abstract: |  This thesis deals with the use of adult-size pulsatile flow ventricular assist device in patients of different size. Hereby, I try to prove basic concept, that substantially larger VAD stroke volume, than to what the patient is used to, would lead to hypertension. This concept has been already multiple times considered (for instance in [suri05, reinhartz01]). There are discussed general properties of human circulatory system, then an overview of mechanical circulatory support devices with emphasize on ventricular assist devices is presented. Based on a paper from Conlon et al.(2006)[conlon06], a mathematical model of systemic circulation is designed and implemented in Modelica language. This model is adjusted to represent either a small, normal-sized or a large patient. Consecutively, there is conducted an experiment on this model, where different VAD stroke volumes are used in patients of different size. According to hypothesis, the hypertension is really caused.
Also, an user interface application for this model is designed and implemented in Silverlight environment, to serve as a learning aid and demonstrational tool.
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