| List |
| Topic: | Korekce pohybu pro ASL (arterial spin labeling) MRI obrazy |
|---|---|
| Department: | Katedra kybernetiky |
| Supervisor: | Ing. Jan Petr, Ph.D. |
| Announce as: | Diplomová práce, Bakalářská práce, Semestrální projekt |
| Description: | Arterial spin labeling (ASL) is an MRI technique that uses
magnetically labeled blood as an endogenous tracer to image cerebral perfusion. Compared to the other techniques for measuring perfusion, it doea not need gadolinium-based contrast-agents or radioactive tracers. Its complete non-invasiveness makes it an ideal candidate for longitudinal perfusion studies or for use in pediatric and healthy populations. The acquisition time of ASL is several minutes, making ASL susceptible to head motion. There are several methods for motion correction. However, these methods were mainly developed for functional MRI and are not so well suited for ASL that has an inherent difference between the control and labeled images. The goal of this project is to develop a motion correction technique adapted for advanced ASL sequences. This technique will use a specialized cost-criterion - brain boundaries, edges, or other more advanced features will be used for the registration. This registration will be tested on a synthetic dataset generated using an ASL-DRO and also on in-vivo datasets. The best approach will be evaluated and implemented within the ExploreASL pipeline. The technical supervision of the project will be guaranteed by Dr. J. Petr (Helmholtz-Zentrum Dresden-Rossendorf, Germany). The project will be done in collaboration with Dr. H. Mutsaerts and B. Padrela (Amsterdam UMC, the Netherlands) who will grant the student access to data, and Dr. A. Oliver-Taylor (GSP Phantom, UK) who will supervise the data generation with the ASL-DRO. The student will work with the ExploreASL software for the ASL data analysis and write custom Matlab scripts for the data evaluation. |
| Bibliography: | Alsop et al. Recommended Implementation of Arterial Spin-Labeled Perfusion MRI for Clinical Applications: A Consensus of the ISMRM Perfusion Study Group and the European Consortium for ASL in Dementia.” Magn Reson Med 2015
Garcia et al. Efficiency of Inversion Pulses for Background Suppressed Arterial Spin Labeling. Magn Reson Med 2005 Gunther et al. Highly efficient accelerated acquisition of perfusion inflow series by cycled arterial spin labeling. ISMRM 2017 Heijtel et al. Accuracy and Precision of Pseudo-Continuous Arterial Spin Labeling Perfusion during Baseline and Hypercapnia: A Head-to-Head Comparison with 15O H2O Positron Emission Tomography. NeuroImage 2014 Hernandez-Garcia et al. Recent Progress in ASL. NeuroImage 2018 Mutsaerts et al. ExploreASL: An Image Processing Pipeline for Multi-Center ASL Perfusion MRI Studies. NeuroImage 2020 Thomas et al. Regional variation of cerebral blood flow and arterial transit time in the normal and hypoperfused rat brain measured using continuous arterial spin labeling MRI. J Cereb Blood Flow Metab 2006 Wang et al. Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx. Magn Reson Imaging 2008 Williams et al. Magnetic Resonance Imaging of Perfusion Using Spin Inversion of Arterial Water Proc Nat Academy Sci 1992. Xie et al. Optimal design of pulsed arterial spin labeling MRI experiments. Magn Reson Med 2008 |