Detail of the student project

Topic:Dlouhodobý vývoj EEG charakteristik epileptických záchvatů
Department:Katedra kybernetiky
Supervisor:Ing. Jan Kudláček, DiS., Ph.D.
Announce as:Diplomová práce, Bakalářská práce, Semestrální projekt
Description:Epilepsy is a brain disorder affecting 0.5 - 1 % of population in developed countries. During an epileptic seizure, changes in effective connectivity were observed in human patients. These changes define the pathway of the seizure within a multidimensional space. Morover, evolution of the pathways was observed in ~1 week long recordings from presurgical intracranial EEG evaluation where multiple seizures were recorded from each patient [1]. Animal models of epilepsy offer the opportunity to record for up to several months and capture many more seizures [2]. Multichannel recordings of continuous long-term intracranial EEG from epileptic laboratory mice and rats will be provided by the Department of Physiology, Second Faculty of Medicine, Charles University in Prague. The goal of the thesis will be to analyze the seizure pathways in a similar manner to [1] and determine the character of the evolution of the seizures, e.g. whether it is monotonous or cyclical. The results will improve the understanding of the long-term dynamics of seizures which may enable forecasting of the seizure risk or inspire the development of novel treatment strategies.
Bibliography:[1] Schroeder GM, Diehl B, Chowdhury FA, Duncan JS, de Tisi J,
Trevelyan AJ, Forsyth R, Jackson A, Taylor PN, Wang Y. Seizure
pathways change on circadian and slower timescales in individual
patients with focal epilepsy. Proc Natl Acad Sci U S A. 2020 May
19;117(20):11048-11058. doi: 10.1073/pnas.1922084117.

[2] Kudlacek J, Chvojka J, Kumpost V, Hermanovska B, Posusta A,
Jefferys JGR, Maturana MI, Novak O, Cook MJ, Otahal J, Hlinka J,
Jiruska P. Long-term seizure dynamics are determined by the nature of
seizures and the mutual interactions between them. Neurobiol Dis. 2021
Jul;154:105347. doi: 10.1016/j.nbd.2021.105347.
Responsible person: Petr Pošík